For many hopeful parents, the road to building a family doesn’t always look how they imagined. The good news is that advances in fertility care have created more pathways to parenthood through what’s known as third-party reproduction, which includes donor eggs, donor sperm, donor embryos and gestational surrogacy.
These family-building pathways help individuals and couples overcome medical, genetic or social barriers to pregnancy while receiving compassionate, highly coordinated care along the way.
What Is Third-Party Reproduction?
Third-party reproduction involves another person helping in the reproductive process to achieve pregnancy. Depending on your situation, this may include:
- Donor eggs
- Donor sperm
- Donor embryos
- A gestational carrier (surrogate)
These options can open new possibilities for people facing fertility challenges— including same-sex couples, single parents by choice, cancer survivors and those with inherited genetic conditions.
When Are Donor Eggs, Sperm or Embryos Recommended?
Every fertility journey is different, but donor options are often considered when pregnancy with a patient’s own eggs or sperm may not be possible or may carry significant medical or genetic concerns.
Donor Eggs May Be Recommended For:
- Diminished ovarian reserve
- Advanced maternal age
- Premature ovarian insufficiency
- Certain genetic conditions
- Patients who have undergone chemotherapy or other gonadotoxic treatments
- Single men or male same-sex couples
Donor Sperm May Be Recommended For:
- Severe male factor infertility
- Single women pursuing parenthood independently
- Female same-sex couples
Donor Embryos May Be Considered When:
- Both egg and sperm factors are involved
- Previous IVF cycles have been unsuccessful
- Patients are open to non-genetic parenthood
Anonymous vs. Known Donors: What’s the Difference?
Patients using donor eggs, sperm or embryos choose between two types of donors:
Anonymous (Non-Identified) Donors
These donors work through an agency or clinic and typically do not have a direct relationship with recipients.
Benefits may include:
- Clear legal boundaries
- Faster matching
- Streamlined screening processes
Things to consider:
- Limited future medical updates
- Potential lack of future contact
- Questions children may have later about biological origins
Directed (Known) Donors
These donors are personally known to the intended parent(s), often a friend or family member.
Benefits may include:
- Greater openness and communication
- Shared cultural or genetic connections
- More personalized donor relationships
Things to consider:
- More complex emotional dynamics
- Additional legal considerations
- Ongoing counseling and support needs
There’s no universally “right” choice. The right choice depends on your family goals, comfort level and long-term vision.
Safety, Screening and Legal Protection Matter
Third-party reproduction follows established medical, ethical and legal safeguards designed to protect everyone involved, specifically the intended parents, donors, gestational carriers and future children.
Comprehensive Screening Includes:
- Infectious disease testing
- Genetic carrier screening
- Full medical evaluations
- Psychological assessments
Donors and gestational carriers undergo extensive reviews to ensure they are physically and emotionally prepared for the process.
Legal agreements are essential
Before treatment begins, all parties work with independent legal counsel to establish:
- Parentage rights
- Privacy and identity agreements
- Future contact expectations
- Embryo and tissue disposition plans
- Financial responsibilities and protections
Because laws vary by state, experienced reproductive legal guidance is critical.
Understanding Gestational Surrogacy
Gestational surrogacy allows another person (called a gestational carrier) to carry a pregnancy created through IVF. The carrier has no genetic relationship to the baby.
This path may be recommended for patients with:
- Uterine conditions
- Recurrent pregnancy loss
- Medical conditions that make pregnancy unsafe
- Same-sex male couples
- Certain cancer survivors
Gestational Carriers Undergo:
- Extensive medical screening
- Mental health evaluations
- Review of prior healthy pregnancies
- Legal consultation and contracts
The process also involves close coordination between fertility specialists, psychologists, nurses and attorneys to ensure a safe and supported experience for everyone involved.
The Emotional Side of Family Building
Third-party reproduction can bring hope, relief, excitement and sometimes grief, anxiety or uncertainty. That’s completely normal.
Many patients benefit from fertility counseling throughout the process, especially when navigating decisions around genetics, disclosure to future children, donor relationships or surrogacy dynamics.
Support matters just as much as science.
You Don’t Have to Navigate This Alone
If you’re exploring donor conception or gestational surrogacy, know this: There are many paths to parenthood, and none of them diminish what it means to become a family.
Today’s fertility care combines advanced medicine, ethical oversight, emotional support and personalized guidance to help patients move forward with confidence and clarity.
No matter where you are in your journey, you deserve compassionate care, clear guidance and options that meet you where you are.
Sources
- Borate GM, Meshram A. Cryopreservation of Sperm: A Review. Cureus. 2022;14(11):e31402. doi:10.7759/cureus.31402. https://pmc.ncbi.nlm.nih.gov/articles/PMC9744399/
- Daudin M, Rives N, Walschaerts M, et al. Sperm cryopreservation in adolescents and young adults with cancer: results of the French national sperm banking network (CECOS). Fertil Steril. 2015;103(2):478-486.e1. doi:10.1016/j.fertnstert.2014.11.012. https://pmc.ncbi.nlm.nih.gov/articles/PMC8444387/
- Oberoi B, Kumar S, Talwar P. Study of human sperm motility post cryopreservation. Med J Armed Forces India. 2014;70(4):349-353. doi:10.1016/j.mjafi.2014.09.006. https://pmc.ncbi.nlm.nih.gov/articles/PMC8444387/
- Su H, Lacchetti C, Letourneau J, et al. Fertility Preservation in People With Cancer: ASCO Guideline Update. J Clin Oncol. 2025;43(12). doi:10.1200/JCO-24-02782. https://ascopubs.org/doi/10.1200/JCO-24-02782
- Practice Committee of the American Society for Reproductive Medicine. Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion. Fertil Steril. 2019;112(6):1022-1033. doi:10.1016/j.fertnstert.2019.09.013. https://pubmed.ncbi.nlm.nih.gov/31843073/
- Babayev SN, Arslan E, Kogan S, et al. Evaluation of ovarian and testicular tissue cryopreservation in children undergoing gonadotoxic therapies. J Assist Reprod Genet. 2013;30(1):3-9. doi:10.1007/s10815-012-9909-5. https://pubmed.ncbi.nlm.nih.gov/23242649/
- Mincheva M, Fraire-Zamora JJ, Sharma K, et al. To be or not to be a sperm donor: global factors affecting sperm donation in the 21st century. Hum Reprod. Published online April 24, 2025. doi:10.1093/humrep/deaf073. https://academic.oup.com/humrep/advance-article/doi/10.1093/humrep/deaf073/8119386
- Calamera JC, Buffone MG, Doncel GF, et al. Effect of thawing temperature on the motility recovery of cryopreserved human spermatozoa. Fertil Steril. 2010;93(3):789-794. doi:10.1016/j.fertnstert.2008.10.021. https://www.sciencedirect.com/science/article/pii/S0015028208042830
- Meseguer M, Garrido N, Remohí J, et al. Testicular sperm extraction (TESE) and ICSI in patients with permanent azoospermia after chemotherapy. Hum Reprod. 2003;18(6):1281-1285. doi:10.1093/humrep/deg260. https://pubmed.ncbi.nlm.nih.gov/12773459/
- Chan PT, Palermo GD, Veeck LL, et al. Testicular sperm extraction combined with intracytoplasmic sperm injection in the treatment of men with persistent azoospermia postchemotherapy. Cancer. 2001;92(6):1632-1637. doi:10.1002/1097-0142(20010915)92:6<1632::AID-CNCR1489>3.0.CO;2-I. https://pubmed.ncbi.nlm.nih.gov/11745242/
- Dickey RP, Pyrzak R, Lu PY, et al. Comparison of the sperm quality necessary for successful intrauterine insemination with World Health Organization threshold values for normal sperm. Fertil Steril. 1999;71(4):684-689. doi:10.1016/s0015-0282(98)00519-6. https://pubmed.ncbi.nlm.nih.gov/10202879/
- Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology. Mature oocyte cryopreservation: a guideline. Fertil Steril. 2013;99(1):37-43. doi:10.1016/j.fertnstert.2012.09.028
- Katler QS, Shandley LM, Hipp HS, Kawwass JF. National egg-freezing trends: cycle and patient characteristics with a focus on race/ethnicity. Fertil Steril. 2021;116(2):528-537. doi:10.1016/j.fertnstert.2021.02.032
- Han E, Seifer DB. Oocyte cryopreservation for medical and planned indications: a practical guide and overview. J Clin Med. 2023;12(10):3542. doi:10.3390/jcm12103542
- Practice Committee of the American Society for Reproductive Medicine. Prevention of moderate and severe ovarian hyperstimulation syndrome: a guideline. Fertil Steril. 2024;121(2):230-245. doi:10.1016/j.fertnstert.2023.11.013
- Wang Z, Zhang D, Zhang H, et al. Characteristics of the patients with adnexal torsion and outcomes of different surgical procedures: a retrospective study. Medicine (Baltimore). 2019;98(5):e14321. doi:10.1097/MD.0000000000014321
- Okoshi C, Takahashi T, Ota K, et al. Severe hemoperitoneum after oocyte retrieval due to ovarian hemorrhage possibly caused by violent cough under general anesthesia with propofol and pentazocine: a case report and literature review. Cureus. 2021;13(10):e18724. doi:10.7759/cureus.18724
- Mesen TB, Mersereau JE, Kane JB, Steiner AZ. Optimal timing for elective egg freezing. Fertil Steril. 2015;103(6):1551-1556.e64. doi:10.1016/j.fertnstert.2015.03.002
- Pai HD, Baid R, Palshetkar NP, et al. Oocyte cryopreservation, current scenario and future perspectives: a narrative review. J Hum Reprod Sci. 2021;14(4):340-349. doi:10.4103/jhrs.jhrs_173_21
- Doyle JO, Richter KS, Lim J, et al. Successful elective and medically indicated oocyte vitrification and warming for autologous in vitro fertilization, with predicted birth probabilities for fertility preservation according to number of cryopreserved oocytes and age at retrieval. Fertil Steril. 2016;105(2):459-466.e2. doi:10.1016/j.fertnstert.2015.10.026
- Cil AP, Bang H, Oktay K. Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis. Fertil Steril. 2013;100(2):492-499.e3. doi:10.1016/j.fertnstert.2013.04.023
- Cobo A, García-Velasco JA, Coello A, et al. Oocyte vitrification as an efficient option for elective fertility preservation. Fertil Steril. 2016;105(3):755-764.e8. doi:10.1016/j.fertnstert.2015.11.027
- Alikani M. Cryostorage of human gametes and embryos: a reckoning. Reprod Biomed Online. 2018;37(1):1-3. doi:10.1016/j.rbmo.2018.05.004
- Katayama KP, Stehlik J, Kuwayama M, et al. High survival rate of vitrified human oocytes results in clinical pregnancy. Fertil Steril. 2003;80(1):223-224. doi:10.1016/S0015-0282(03)00551-X
- Torra-Massana M, Miguel-Escalada I, Vassena R, Rodríguez A. Long-term storage of vitrified oocytes does not affect pregnancy and live birth rates: analysis of 5362 oocyte donation cycles. Reprod Biomed Online. 2023;47(3):103228. doi:10.1016/j.rbmo.2023.04.019
- Walker Z, Lanes A, Ginsburg E. Oocyte cryopreservation review: outcomes of medical oocyte cryopreservation and planned oocyte cryopreservation. Reprod Biol Endocrinol. 2022;20(10). doi:10.1186/s12958-021-00884-0
- Kashir J, Ganesh D, Jones C, Coward K. Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application. Hum Reprod Open. 2022;2022(2):hoac003. doi:10.1093/hropen/hoac003
- Johnston M, Fuscaldo G, Zndder-Fox D, et al. “What am I going to do with those eggs”: patients’ experience of and attitudes toward surplus frozen eggs. Reprod Biomed Online. 2025;[Epub ahead of print]. doi:10.1016/j.rbmo.2025.03.015
- Greenwood EA, Pasch LA, Hastie J, et al. To freeze or not to freeze: decision regret and satisfaction following elective oocyte cryopreservation. Fertil Steril. 2018;109(6):1097-1104.e1. doi:10.1016/j.fertnstert.2018.02.127
- SART. All SART Member Clinics: Report ending 2022. Society for Assisted Reproductive Technology. https://www.sartcorsonline.com/rptCSR_PublicMultYear.aspx. Accessed May 5, 2025.
- Oktay K, Sonmezer M. Fertility preservation: cryopreservation options. UpToDate. https://www.uptodate.com/contents/fertility-preservation-cryopreservation-options. Accessed May 5, 2025.
- Busso C, Soares S, Pellicer A. Management of ovarian hyperstimulation syndrome. UpToDate. https://www.uptodate.com/contents/management-of-ovarian-hyperstimulation-syndrome. Accessed May 5, 2025.
- Cleveland Clinic. Ovarian hyperstimulation syndrome. https://my.clevelandclinic.org/health/diseases/17972-ovarian-hyperstimulation-syndrome-ohss. Accessed May 5, 2025.
- Taylor B, Min J. Ovarian hyperstimulation syndrome: diagnosis, prevention and management. Canadian Fertility and Andrology Society. https://cfas.ca/_Library/clinical_practice_guidelines/CFAS_CPG_OHSS_Guideline_2013.pdf. Accessed May 5, 2025.
- Time Magazine. What you really need to know about egg freezing. Time. July 16, 2015. https://time.com/3959487/egg-freezing-need-to-know/. Accessed May 5, 2025.
- National Public Radio. More women are freezing their eggs, will they ever use them? NPR. November 24, 2015. https://www.npr.org/sections/health-shots/2015/11/24/456671203/more-women-are-freezing-their-eggs-but-will-they-ever-use-them. Accessed May 5, 2025.
- Lazarony L. How much does it cost to freeze eggs? Investopedia. https://www.investopedia.com/the-cost-to-freeze-eggs-11680790. Accessed May 5, 2025.
- Stahl L, Chasan A, Finkelstein S, Richards C. The ins and outs of egg freezing: from how the process works to how much it costs. 60 Minutes. https://www.cbsnews.com/news/egg-freezing-process-costs-60-minutes/. Accessed May 5, 2025.
- Das Gupta S. The emotional and social complexities of egg freezing. Psychology Today. January 8, 2025. https://www.psychologytoday.com/gb/blog/creating-2-pink-lines/202501/the-emotional-and-social-complexities-of-egg-freezing. Accessed May 5, 2025.
- Ho J. In vitro fertilization: Overview of clinical issues and questions. UpToDate. https://www.uptodate.com/contents/in-vitro-fertilization-overview-of-clinical-issues-and-questions. Accessed May 6, 2025.
- Practice Committee of the American Society for Reproductive Medicine; Practice Committee for the Society for Assisted Reproductive Technology. Gamete and embryo donation guidance. Fertil Steril. 2024;122(5):799-813. doi:10.1016/j.fertnstert.2024.06.004
- Wang XJ, Chen MX, Ruan LL, et al. Study on the optimal time limit of frozen embryo transfer and the effect of a long-term frozen embryo on pregnancy outcome. Medicine (Baltimore). 2024;103(13):e37542. doi:10.1097/MD.0000000000037542
- Cleveland Clinic. Embryo Freezing (Cryopreservation). https://my.clevelandclinic.org/health/treatments/15464-embryo-freezing-cryopreservation. Accessed May 7, 2025.
- Cleveland Clinic. Anesthesia. https://my.clevelandclinic.org/health/treatments/15286-anesthesia
- El-Shawarby S, Margara R, Trew G, Lavery S. A review of complications following transvaginal oocyte retrieval for in-vitro fertilization. Hum Fertil (Camb). 2004;7(2):127-133. doi:10.1080/14647270410001699081
- Practice Committees of the American Society for Reproductive Medicine; Society for Assisted Reproductive Technology. Intracytoplasmic sperm injection (ICSI) for non-male factor indications: a committee opinion. Fertil Steril. 2020;114(2):239-245. doi:10.1016/j.fertnstert.2020.05.032
- Mohebi M, Ghafouri-Fard S. Embryo developmental arrest: Review of genetic factors and pathways. Gene Rep. 2019;17. https://www.sciencedirect.com/science/article/abs/pii/S2452014419301219
- Mayo Clinic. In vitro Fertilization. https://www.mayoclinic.org/tests-procedures/in-vitro-fertilization/about/pac-20384716. Accessed May 6, 2025.
- SART National Summary Report. Preliminary Clinic Summary Report for 2016. Society of Assisted Reproductive Technology; 2018. http://www.sartcorsonline.com/rptCSR_PublicMultYear.aspx?reportingYear=2016. Accessed October 25, 2018.
- Nagy ZP, Shapiro D, Chang CC. Vitrification of the human embryo: a more efficient and safer in vitro fertilization treatment. Fertil Steril. 2020;113(2):241-247. doi:10.1016/j.fertnstert.2019.12.009
- Baradaran Bagheri R, Bazrafkan M, Sabour A, et al. The comparison of pregnancy outcomes in fresh and frozen embryo transfer: A cross-sectional study. Int J Reprod Biomed. 2023;21(7):551-556. doi:10.18502/ijrm.v21i7.13891
- Pavlovic ZJ, Smotrich GE, New EP, et al. Fresh vs. frozen: pregnancy outcomes and treatment efficacy between fresh embryo transfer vs. untested freeze-all cycles. F S Rep. 2024;5(4):369-377. doi:10.1016/j.xfre.2024.09.003
- Yu EJ, Kim MJ, Park EA, Kang IS. Preimplantation genetic testing for aneuploidy: The management of mosaic embryos. Clin Exp Reprod Med. 2022;49(3):159-167. doi:10.5653/cerm.2022.05393
