Impact of excess vitamin B12 on pregnancy
Very high levels of vitamin B12 during pregnancy can almost triple the risk that the child develops autism spectrum disorder. In pregnant women who have both excess vitamin B12 and excess folate, the risk for autism increases 17.6 times.
Autism is a developmental disability that affects a person’s social skills, nonverbal communication, and behavior. Signs of autism usually become apparent around age 2 or 3, but in some cases, it can be diagnosed at 18 months. Asperger syndrome is a form of autism.
Potential causes of excess vitamin B12
Excess vitamin B12 is generally due to taking high-dose supplements. It may happen following treatment with injectable vitamin B12 for a deficiency or vitamin B12 deficiency anemia. Eating a lot of meat can also raise your vitamin B12 levels.
High vitamin B12 is also found in people with the following health conditions:
- Blood disorders (leukemia, polycythemia vera, and hypereosinophilic syndrome)
- Liver disease
- Diabetes
- Kidney failure
Symptoms of excess vitamin B12
High doses of vitamin B12 may cause the following symptoms:
- Headache
- Nausea
- Vomiting
- Diarrhea
- Fatigue
- Tingling in the hands and feet
Diagnosis of excess vitamin B12
You can find out your vitamin B12 status through a blood test. Because excess vitamin B12 can be a sign of other health conditions, you may have additional lab tests done.
Treatment
To reduce your vitamin B12 intake and get to a safe level for pregnancy, you can adjust your diet. Animal products, including fish, shellfish, meat, poultry, eggs, and dairy are high in vitamin B12, so you can switch to more plant-based foods. Some breakfast cereals are fortified with this vitamin, so check the nutritional label before buying. Additionally, you should stop taking vitamin B12 supplements.
You can work together with a LEVY nutritionist to come up with a personalized meal plan and ensure you are getting all the right amounts of the necessary vitamins to boost your fertility and protect your baby’s health.
If your doctor finds that you have an underlying health condition linked to your high vitamin B12 level, you will have treatment to manage the condition. For instance, diabetes is treated with insulin and/or diabetes medications like metformin, along with lifestyle changes, which help to control blood sugar levels and significantly improve fertility.
- Ermens A A M et al.: Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem. 2003;36(8):585-590.
- Vitamin B-12. Mayo Clinic. Accessed 11 January 2023.
- Vitamin B12. National Institutes of Health – Office of Dietary Supplements. Accessed 11 January 2023.
- Vitamin B12. MedlinePlus. Accessed 12 January 2023.
- Raghaven R et al.: Maternal Multivitami Intake, Plasma Folate and Vitamin B12 Levels and Autism Spectrum Disorder Risk in Offspring. Paediatr Perinat Epidemiol. 2018;32(1):100-111.
- Morales-Gutierrez J et al.: Toxicity induced by multiple high doses of vitamin B12 during pernicious anemia treatment: a case report. Clin Toxicol (Phila). 2020;58(2):129-131.
- Too Much Folate in Pregnant Women Increases Risk for Autism, Study Suggests. Johns Hopkins Bloomberg School of Public Health. Accessed 12 January 2023.
- What Is Autism? Autism Speaks. Accessed 12 January 2023.
- What Is a Vitamin B-12 Test? Healthline. Accessed 12 January 2023.
- What is the purpose of a vitamin B-12 level test? Medical News Today. Accessed 12 January 2023.

